Down Syndrome and Van Wyk-Grumbach Syndrome: A Rare Presentation
نویسندگان
چکیده
Van Wyk-Grumbach Syndrome (VWGS) is presented by juvenile hypothyroidism, delayed bone age and isosexual precocious puberty. All of the features will be reversed with treatment underlying thyroid hormone deficiency. It has been described, a 3- year-old girl Down who per vaginal bleeding. Physical examination showed typical morphologic hypothyroidism. Pubertal developments in tanner stages were: breast at stage II pubic hair I. Serum TSH level was very high. FSH, LH Estrogen were also high for her age. On radiological 2 years. Her pelvic sonogram revealed enlarged uterus ovarian cysts. These findings confirmed diagnosis VWGS. Treatment Levothyroxine, bleeding did not recur cyst size decreased after 4 weeks disappeared months. In conclusion, hypo-function must investigated children have puberty multicystic ovaries. JAFMC Bangladesh. Vol 18, No 1 (June) 2022: 97-99
منابع مشابه
An unusual presentation of girl with down syndrome: Van-Wyk Grumbach syndrome
Van Wyk-Grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. A9 year-old girl with Down syndrome visited our hospital for early menarche. At birth, she showed subclinical hypothyroidism (11.8 mg/dL of thyroxine (T4) and 6.05 mIU/mL of thyroid stimulating hormone (TSH)), but she had not been followed up...
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ژورنال
عنوان ژورنال: Journal of Armed Forces Medical College, Bangladesh
سال: 2022
ISSN: ['2224-7327', '1992-5743']
DOI: https://doi.org/10.3329/jafmc.v18i1.61270